Study on Second-line Helicobacter pylori Infection Eradication Therapy Based on CYP2C19 Genetic Polymorphism
نویسندگان
چکیده
منابع مشابه
Influence of CYP2C19 functional polymorphism on Helicobacter pylori eradication.
BACKGROUND/AIMS Proton pump inhibitors are mainly metabolized by cytochrome P450 2C19 in the liver. Recently, some studies have shown that the acid suppressing effect of proton pump inhibitors are influenced by a functional polymorphism of cytochrome P450 2C19. The aim of the present study was to investigate the effect of cytochrome P450 2C19 polymorphism on Helicobacter pylori eradication in p...
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Materials and methods: Th is is a prospective, open-label, single-centre study. Th e study involved 86 consecutive patients with nonulcer dyspepsia. All patients were randomly assigned into 2 study groups at a 2:1 ratio using random sampling numbers. Th e fi rst group of patients were administered a sequential treatment: pantoprazole 2 × 40 mg and amoxicillin 2 × 1000 mg for the fi rst 7 days a...
متن کاملImportance of CYP2C19 genetic polymorphism in the eradication of Helicobacter pylori in north Indians.
BACKGROUND & OBJECTIVES Genetic polymorphism of CYP2C19 is known to occur with a frequency of 12 per cent in north Indian population. But no study correlated CYP2C19 genetic polymorphism with eradication of Helicobacter pylori in north Indian gastritis patients positive for H. pylori and hence this study. METHODS Ninety one consecutive patients positive for H. pylori fulfilling the study crit...
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Currently, a standard third-line therapy for Helicobacter pylori (H. pylori) eradication remains to be established. Quinolones show good oral absorption, no major side effects, and marked activity against H. pylori. Several authors have studied quinolone-based third-line therapy and reported encouraging results, with the reported H. pylori cure rates ranging from 60% to 84%. Resistance to quino...
متن کاملefficacy of clarithromycin containing bismuth–based regimen as a second-line therapy in helicobacter pylori eradication
background: the eradication of helicobacter pylori infection, commonly prevailing in the stomach, has been important since its introduction. adequate preparations should be made in finding alternatives when faced with first-line treatment failures. currently, ideal second-line treatments are indistinct and varied among countries as result of different antibiotic resistance patterns. we aimed to...
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ژورنال
عنوان ژورنال: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
سال: 2007
ISSN: 1882-1499,1346-342X
DOI: 10.5649/jjphcs.33.251